Vacant job

Lund University was founded in 1666 and is consistently ranked among the world's leading universities. We have approximately 46,000 students and 8,500 employees in Lund, Helsingborg, and Malmö. We are united in our strive to understand, explain, and improve our world and the conditions of human life.

Description of the Activity

We offer a doctoral position for research within neuroscience.

The work in the Glia-Immune Interactions laboratory is centered around the glial-lymphatic (glymphatic) system, which is a clearance system for solutes and proteins in the brain, and its role in CNS diseases. Disruption of the system in disease and aging can increase susceptibility to the development of neurodegenerative diseases, or may exacerbate pathology in neurodegenerative diseases.

The goal of the work in our laboratory is to gain a deeper understanding of the glymphatic system and its role in neurodegenerative diseases. The lab uses animal disease models and in vivo imaging to study the glymphatic system in health and disease. The research is highly translational and uses models relevant to human diseases.

The activity is located at the Biomedical Center in Lund. Within the research group, we value a good work environment characterized by respect and care in our relationships with each other. We constantly work to create conditions for job satisfaction, development, and participation for all group members. The group is international and regularly hosts guest researchers as well as master's students.

Project Description

We are seeking a doctoral student for a project related to the glymphatic system and Alzheimer's disease, using small animal models, primarily mice, and large animal models, primarily pigs.

Tasks and Responsibilities

The main task for the doctoral student is to engage in doctoral education within the project. The overarching goal of the project is to define mechanisms for glymphatic-targeted treatment strategies and to validate selected therapeutic candidates and diagnostic tools in mouse and pig models.

You will conduct experimental research with a special focus on Alzheimer's disease. Your work will involve the development and use of preclinical methods to investigate glymphatic clearance and brain metabolism in both large animal models and mouse models.

You will have specific responsibility for contributing to the development and optimization of a brain clearance assay in pigs, including studies on the pharmacological modulation of glymphatic function.

You will also work with mouse models of amyloid pathology to study hippocampal cerebral blood flow, metabolism, and histopathology using MRI and microscopy. Your tasks will include experimental planning, data collection, image and spectroscopy analysis, statistical analysis, documentation, interpretation of results, and preparation of scientific manuscripts.

You will present research findings at group meetings, seminars, and scientific conferences, and you will contribute to a collaborative and responsible research environment.

The work will be carried out in close collaboration with supervisors and other members of the research group, but you are also expected to be able to work independently and gradually take increased responsibility for the implementation of the project.

Qualifications

Requirements for admission are:

• A completed advanced level degree, or
• Completed course requirements of at least 240 higher education credits, of which at least 60 higher education credits at an advanced level, or
• Acquired substantially equivalent knowledge in some other way, within or outside the country.
• Good ability to benefit from doctoral education.

Requirements for employment are:

• Educational background in medicine, biomedicine, neuroscience, neurobiology, or another subject relevant to the project.
• Fluent English, both spoken and written.
• Good ability to communicate in Swedish, both spoken and written, to participate in Swedish-language educational modules, contribute to work with ethical applications, and communicate with staff at the pig facility.

See the full announcement via link: https://lu.varbi.com/what:job/jobID:935563/ (https://lu.varbi.com/what:job/jobID:935563/)