Postdoctoral Researcher in Wet Laboratory

The Department of Biochemistry and Biophysics consists of about 250 people, including around 60 PhD students.

The department conducts world-class education and research.

In addition to our research groups in Frescati, we have several groups and national facilities located at SciLifeLab. SciLifeLab is a national center with the overarching goal of facilitating the intersection of cutting-edge, interdisciplinary research in life sciences.

More information about us can be found at: https://www.su.se/department-of-biochemistry-and-biophysics/ (https://www.su.se/department-of-biochemistry-and-biophysics/).

Project Description

Our research group studies the epigenetic regulation of human brain development under normal and pathological conditions. We develop and apply groundbreaking single-cell, multimodal, and spatial genomics techniques to understand how regulatory programs shape development, disease, and evolution. We have previously developed methods for multimodal single-cell profiling of histone modifications and chromatin accessibility (Bartosovic et al., Nature Biotech., 2021; Bartosovic et al., Nature Biotech., 2022) and for spatially resolved epigenome mapping (Deng, Bartosovic et al., Science 2022; Zhang et al., Nature, 2023).

We are now recruiting a postdoctoral researcher in a wet laboratory to apply these techniques to stem cell-based neurological development models to map human brain development and identify dysregulated regulatory programs relevant to autism spectrum disorder (ASD). The project combines 2D/3D differentiation models with high-resolution chromatin profiling and functional perturbation to link non-coding risk variation to cell types, regulatory elements, and molecular mechanisms.

Responsibilities

• Culture and maintain human pluripotent stem cells (iPSC/ESC).
• Develop and implement 2D and 3D models of human brain development.
• Genome/epigenome editing using CRISPR-based methods.
• Apply advanced single-cell, multimodal, and spatial epigenomic profiling techniques.
• Collaborate with other members of the research group.
• Supervise master's and PhD projects.
• Write reports, manuscripts, and documentation.
• Prepare presentations and participate in international conferences.

Eligibility Requirements

A researcher is primarily employed for research and must have obtained a PhD or have a foreign degree that is assessed to be equivalent to a PhD.

Assessment Criteria

In the appointment process, special emphasis will be placed on scientific competence as well as:

• PhD in stem cell biology, developmental neurobiology, molecular biology, or a related field.
• Strong practical experience with human pluripotent stem cells (maintenance, differentiation, troubleshooting), preferably within neural lines/organoids.
• Solid background in molecular and cellular methods (e.g., PCR/qPCR, cloning, immunocytochemistry/IHC, microscopy, western blot).
• Ability to work rigorously with complex protocols and iterative method optimization.
• Experience in epigenomics (e.g., ATAC, CUT&Tag/CUT&RUN/ChIP-like methods), single-cell workflows (e.g., 10x), spatial methods, and/or CRISPR perturbation methods.
• Team-oriented attitude and strong communication skills in English.

About the Position

The position is part-time (65%) and is limited to a maximum of 12 months. Start date 2026-04-01.

We Offer

With us, you will experience the dynamics of the interplay between higher education and research that makes Stockholm University an exciting and creative environment. You will work in an international setting and enjoy favorable conditions. The university is located in the National City Park with good connections to the city.

Stockholm University is committed to being a workplace free from discrimination and providing equal rights and opportunities for all.

Contact

Inquiries about the position can be made to researcher Marek Bartosovic, [email protected] (mailto:[email protected]).

Application

You apply for the position via Stockholm University's recruitment system. Please attach a personal letter and CV as well as the requested attachments in the application form. As an applicant, you are responsible for ensuring that your application is complete and that it reaches the university by the deadline.

Instructions for applicants can be found on the website: https://www.su.se/om-universitetet/jobba-på-su/att-söka-en-anställning (https://www.su.se/om-universitetet/jobba-p%C3%A5-su/att-s%C3%B6ka-en-anst%C3%A4llning).

Stockholm University contributes to the development of a sustainable democratic society through knowledge, enlightenment, and the pursuit of truth.