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The Department of Clinical Sciences is one of six departments at the Sahlgrenska Academy at the University of Gothenburg. Research and education are conducted at the department, focusing on human health and quality of life. We represent 16 different subject areas and are divided into four sections. Through a enriching collaboration with healthcare and Sahlgrenska University Hospital, we have developed joint projects and meeting places that benefit both care and research.

The position is located at the Department of Urology and involves close collaboration between experimental and clinical research. Within the field of urology at the Sahlgrenska Academy, research and development are ongoing regarding diseases of the urinary tract and male reproductive organs. Urology is the second largest single cancer specialty after oncology. It accounts for approximately one-quarter of all cancer cases and constitutes one-third of all cancers affecting men, with prostate cancer being the most common form.

The Promeniche project aims to investigate the mechanisms through which prostate cancer cells metastasize to the skeleton. Specifically, how tumor-derived extracellular vesicles/exosomes or other blood-borne mediators affect the bone marrow microenvironment and contribute to the formation of pre-metastatic niches, which in turn enable the establishment of metastases. The project combines material from patient samples, experimental mouse models, and molecular analyses to identify biological mechanisms and potential biomarkers associated with metastatic progression.

Subject

Urological cancer research

Subject Description

The project is conducted at the Department of Urology but is primarily based at the Sahlgrenska Center for Cancer Research (SCCR). The primarily clinical research subject of urology is complemented here by biomedicine, cell biology, and molecular biology.

Responsibilities

The Promeniche research project conducts translational research on prostate cancer with a focus on liquid biopsies, the bone marrow microenvironment, and metastatic progression. The project includes experimental studies with mouse models, handling of patient samples, as well as molecular and cellular analyses of tumor-associated systemic signaling.

The employment involves planning and conducting experimental studies within the Promeniche project.

The tasks include:

• Establishment and work with experimental mouse models, including prostate surgery, intravenous injections, and bone marrow analyses
• Optimization of methods for handling patient samples and isolation of extracellular vesicles/exosomes from plasma and cell cultures
• Cell culture and work with prostate cancer cell lines
• Flow cytometric analyses of hematopoietic and myeloid cell populations
• Participation in molecular analyses such as RNA sequencing, proteomics, and bioinformatic analyses in collaboration with other researchers and/or core facilities
• Compilation and presentation of scientific results in manuscripts and at scientific conferences
• Supervision of master's students

Qualifications

Eligible for employment as a postdoctoral researcher is someone who has completed a PhD, a doctoral degree in the arts, or has a foreign degree assessed as equivalent to a PhD. This eligibility requirement must be met no later than the time when the employment decision is made.

Priority should be given to those who have completed their degree no more than three years before the application deadline. Those who completed their degree earlier should also be considered in priority if there are special reasons. Special reasons include leave due to illness, parental leave, trust positions within trade unions, service in the total defense, or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.

Assessment Criteria

A PhD in a relevant field such as cancer biology, molecular biology, immunology, experimental medicine, or equivalent is required.

The applicant must have the following qualifications:

• Expertise in in vivo modeling, preferably including genetically modified mouse models.
• Microsurgery on mice, with a particular focus on the prostate.
• Expertise in prostate/prostate cancer biology and growth signaling, particularly in relation to bone marrow biology.
• Expertise in cell culture.
• Experience with tissue handling, histology, and molecular biological methods.

Experience with flow cytometry, extracellular vesicles/exosomes, bioinformatic knowledge for analyzing data from RNA sequencing or proteomics, and handling of patient-derived material is considered meritorious.

Great emphasis will be placed on scientific independence, teamwork skills, and the ability to drive projects forward.

For more information and to apply for the position, see the full announcement at https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar (https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar).

The University actively works for a working environment with equal conditions and values the qualities that diversity brings to the operations. The University applies individual salary setting. According to the National Archives' regulations, the University is required to keep application documents for two years after the appointment decision. If you as an applicant specifically request the return of your documents, they will be returned when the two years have passed; otherwise, they will be destroyed. To staffing and recruitment agencies and to you who are sellers: The University of Gothenburg uses a procured advertising agency in connection with the recruitment of staff. We kindly but firmly decline direct contact with staffing and recruitment agencies as well as sellers of job advertisements.

Open to all
We focus on your competence, not your other prerequisites. We are open to adapting the role or workplace to your needs.