Vacant job

Department of Pharmaceutical Biosciences

The Department of Pharmaceutical Biosciences is an interdisciplinary environment where 10 research areas work to contribute to better medicines and a healthier world. With laboratories at the heart of the Uppsala Biomedical Centre and Sweden's only Faculty of Pharmacy, we form a vital engine in the development of education and research within pharmaceutical sciences. More information about the department and its activities can be found at uu.se/farmbio.

We offer a postdoc position within a NEST initiative funded by the Wallenberg Foundation's national programs for data-driven life sciences (DDLS) and the Wallenberg AI, Autonomous Systems and Software Program (WASP). The project, Time-Resolved Imaging and Multi-Channel Evaluation of Cellular Dynamics (TIMED), is a five-year collaboration between researchers at Uppsala University, Chalmers University of Technology, and Karolinska Institutet. Within the TIMED project, we are developing new methods to study cancer and its dynamics by integrating artificial intelligence and data analysis with time-series. By studying dynamic biological processes, such as cell behavior and response over time, we enable a systematic characterization of fundamental cellular processes on a large scale.

Responsibilities

The project involves establishing cell line panels and developing and applying CRISPR-based perturbation systems combined with morphological profiling to map how genetic changes affect cellular phenotypes. A central scientific goal is to use high-content imaging of live and fixed cell lines to link genotype to morphological and functional phenotype, as well as to interpret biological responses in terms of signaling pathways. Within the TIMED project, you will collaborate with doctoral students and senior researchers with complementary expertise in image and data analysis, artificial intelligence, and cancer biology.

More specifically, you will:

• Develop and validate stable genetically modified cell lines.
• Plan and conduct CRISPR perturbation experiments in cell lines.
• Perform high-content imaging of live cells using the laboratory's robotic lab.
• Interpret results and place them in a biological context.
• Contribute to data analysis to link genetic perturbations to phenotypic outcomes.

Qualifications

• A PhD in a relevant field of experimental laboratory work.
• The degree must be completed no later than at the time the employment decision is made. Preference is given to those who have obtained their degree within the last three years. When calculating the three-year timeframe, the starting point is the last day of application. In exceptional cases, a degree obtained earlier may be considered.
• Experience with molecular biology techniques for cell engineering.
• At least three years of practical experience in cell culture and quantitative cell-based assays.
• Experience with high-content fluorescence microscopy, automated microscopy, and image analysis.
• Good teamwork skills and experience working across research group or departmental boundaries.
• Very good oral and written communication skills in English.

Great importance is attached to personal suitability, motivation, and genuine interest in research in the field.

About the position

Fixed-term employment for 24 months according to the central collective agreement. The position is full-time. Start date: 2026-09-01 or by agreement. Location: Uppsala.

Information about the position is provided by Professor Ola Spjuth, email: [email protected]

For questions regarding the employment Administrative Manager Marina Rönngren, email: [email protected]

Please submit your application by June 23, 2026, Ref: UFV-PA 2026/1925

Uppsala University is a broad research university with a strong international standing. The ultimate goal is to conduct education and research of the highest quality and relevance to make a difference in society. Our most important asset is all 7,500 employees and 53,000 students who, with curiosity and engagement, make Uppsala University one of the country's most exciting workplaces.

Read more about our benefits and what it is like to work at Uppsala University: https://uu.se/om-uu/jobba-hos-oss/ (https://uu.se/om-uu/jobba-hos-oss/)

The employment may be subject to a security clearance. In the case of a security clearance, a prerequisite for employment is that the applicant is approved.

We decline offers of recruitment and advertising assistance.

Applications are received in Uppsala University's recruitment system.

Trade union representatives: Saco-S - [email protected], Seko - [email protected], ST (OFR/S) - [email protected]