Job Advertisement: Researcher in Genome Editing

The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focused on cancer, genetic and autoimmune diseases. One of the core ideas at the department is to stimulate translational research and thereby promote closer collaboration between medical research and healthcare. Research is conducted within six research programs: cancer precision medicine, cancer immunotherapy, genomics and neurobiology, molecular tools and functional genomics, neuro-oncology and neurodegeneration, and vascular biology. Parts of the operations are also integrated with the departments of oncology, clinical genetics, clinical immunology, clinical pathology, and hospital physics at Uppsala University Hospital. The department has teaching assignments in several program educations, independent courses, and international master's programs within the Faculty of Medicine and the Faculty of Science and Technology. The department has a turnover of approximately 550 million SEK, of which about two-thirds are external research grants. The number of employees is approximately 400, of which about 100 are doctoral students, and there are a total of over 850 active in the workforce. Please read more about the department's activities here: http://www.uu.se/medarbetare/institution/immunologi-genetik-och-patologi (http://www.uu.se/medarbetare/institution/immunologi-genetik-och-patologi)

Job Responsibilities:

You will use advanced genome editing methods to introduce and study hereditary or acquired mutations in colorectal cancer genes and in genes that are potential targets for drug treatment aimed at loss of heterozygosity. The work will primarily be conducted using the CRISPR-Select method. You will use spheroid models to study the effects of mutations on cells growing in 3D. You will characterize cellular effects and phenotypes of the mutations using methods such as Western Blotting, FACS analysis, trans-well migration assays, viability assays, and confocal microscopy.

Qualifications:

Master's degree in molecular biology, genetics, or equivalent.

Desirable and/or Meritorious:

Experience with cell culture of colorectal cancer cells in 2D and 3D, Western Blotting, FACS analysis, trans-well migration assays, viability assays, and confocal microscopy.

About the Employment

The position is permanent, with a probationary period possible. The extent is full-time. Start date by agreement. Location: Uppsala

For inquiries about the position, please contact: Tobias Sjöblom, [email protected] (mailto:[email protected])

Welcome with your application no later than September 1, 2025, UFV-PA 2025/1783.

Uppsala University is a broad research university with a strong international standing. The ultimate goal is to conduct education and research of the highest quality and relevance to make a difference in society. Our most important asset is all 7,600 employees and 53,000 students who, with curiosity and commitment, make Uppsala University one of the country's most exciting workplaces.

Read more about our benefits and what it is like to work at Uppsala University https://uu.se/om-uu/jobba-hos-oss/ (https://uu.se/om-uu/jobba-hos-oss/)

The employment may be subject to security clearance. A condition for employment during security clearance is that the applicant is approved.

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Applications are received in Uppsala University's recruitment system.